Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

anagrelide hydrochloride
Synonyms

Thromboreductin

Agrylin
Definitions

The hydrochloride salt of a synthetic quinazoline derivative, anagrelide hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28826" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28826" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000759095
altLabel

Thromboreductin

Agrylin
cui

C4733406

C0771907

C0718300
DATE FIRST PUBLISHED

2014-03-12
Date last modified

2014-03-12
definition

The hydrochloride salt of a synthetic quinazoline derivative, anagrelide hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28826" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28826" NCI Thesaurus)
LT

TRD
NCI ID

C28826
notation

CDR0000759095
ORIG STY

Drug/agent
prefLabel

anagrelide hydrochloride
tui

T109

T121
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