Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

neomycin
Synonyms

neomycin complex

Definitions

A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C683" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C683" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000755934

altLabel

neomycin complex

CAS Registry

1404-04-2

cui

C0027603

DATE FIRST PUBLISHED

2013-12-16

Date last modified

2017-03-30

definition

A broad spectrum aminoglycoside antibiotic derived from Streptomyces fradiae with antibacterial activity. Neomycin is an antibiotic complex consisting of 3 components: the two isomeric components B and C are the active components, and neomycin A is the minor component. Neomycin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, neomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C683" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C683" NCI Thesaurus)

NCI ID

C683

notation

CDR0000755934

ORIG STY

Drug/agent

prefLabel

neomycin

tui

T109

T195

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/ATC/R02AB01 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/73093001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/A07AA01 ATC CUI
http://purl.bioontology.org/ontology/NDDF/002775 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/373528008 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-52550 SNMI CUI
http://purl.bioontology.org/ontology/ATC/S01AA03 ATC CUI
http://purl.bioontology.org/ontology/RXNORM/7299 RXNORM CUI
http://purl.bioontology.org/ontology/CSP/0191-8317 CRISP CUI
http://purl.bioontology.org/ontology/ATC/S02AA07 ATC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146336 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D009355 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D009355 MESH CUI
http://purl.bioontology.org/ontology/RCD/X79Di RCD CUI
http://purl.bioontology.org/ontology/ATC/D06AX04 ATC CUI
http://purl.bioontology.org/ontology/LNC/LP15001-8 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/73093001 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/MTHU002304 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373528008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/x01HJ RCD CUI
http://purl.bioontology.org/ontology/ATC/S03AA01 ATC CUI
http://purl.bioontology.org/ontology/ATC/J01GB05 ATC CUI
http://purl.bioontology.org/ontology/VANDF/4017991 VANDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006423 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/B05CA09 ATC CUI
http://purl.bioontology.org/ontology/ATC/A01AB08 ATC CUI
http://purl.obolibrary.org/obo/CHEBI_7507 DRON LOOM
http://purl.obolibrary.org/obo/ARO_0000005 ARO LOOM
http://purl.bioontology.org/ontology/ATC/R02AB01 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 VICO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 OVAE LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 VO LOOM
http://purl.obolibrary.org/obo/CHEBI_7507 ZP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D009355 RH-MESH LOOM
http://purl.obolibrary.org/obo/HIO_0000284 HIO LOOM
http://purl.bioontology.org/ontology/ATC/A07AA01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0027603 OCHV LOOM
http://purl.obolibrary.org/obo/dinto_DB00994 DINTO LOOM
http://purl.bioontology.org/ontology/NDDF/002775 NDDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-52550 SNMI LOOM
http://purl.bioontology.org/ontology/ATC/S01AA03 ATC LOOM
http://purl.obolibrary.org/obo/XCO_0001210 XCO LOOM
http://purl.bioontology.org/ontology/RXNORM/7299 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/0191-8317 CRISP LOOM
http://purl.bioontology.org/ontology/ATC/S02AA07 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146336 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D009355 MESH LOOM
http://purl.bioontology.org/ontology/RCD/X79Di RCD LOOM
http://purl.bioontology.org/ontology/ATC/D06AX04 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP15001-8 LOINC LOOM
http://purl.obolibrary.org/obo/MESH_D009355 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.623 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C683 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002304 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0010383 OMIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373528008 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C683 NCIT LOOM
http://purl.bioontology.org/ontology/ATC/S03AA01 ATC LOOM
http://purl.bioontology.org/ontology/ATC/J01GB05 ATC LOOM
http://purl.jp/bio/4/id/200906063975820929 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017991 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/B05CA09 ATC LOOM
http://purl.bioontology.org/ontology/ATC/A01AB08 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020962 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8554 OCHV LOOM
https://go.drugbank.com/drugs/DB00994 MDM LOOM
http://www.co-ode.org/ontologies/galen#Neomycin GALEN LOOM