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Physician Data Query
| Preferred Name | ezetimibe | |
| Synonyms |
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone ezedoc Zetia |
|
| Definitions |
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47529" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47529" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000754008 |
|
| altLabel |
1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone ezedoc Zetia
|
|
| CAS Registry |
163222-33-1
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|
| cui |
C1142985 C1707992 C1170736
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|
| DATE FIRST PUBLISHED |
2013-10-24
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| Date last modified |
2014-01-09
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|
| definition |
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47529" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47529" NCI Thesaurus)
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|
| LT |
TRD
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| NCI ID |
C47529
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|
| notation |
CDR0000754008
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|
| ORIG STY |
Drug/agent
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|
| prefLabel |
ezetimibe
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|
| tui |
T109 T121
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