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Physician Data Query
| Preferred Name | insulin lispro | |
| Synonyms |
Humalog |
|
| Definitions |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000752177 |
|
| altLabel |
Humalog
|
|
| CAS Registry |
133107-64-9
|
|
| cui |
C0293359 C0528249
|
|
| DATE FIRST PUBLISHED |
2013-09-04
|
|
| Date last modified |
2013-09-04
|
|
| definition |
A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin. In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration. Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration. Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues.
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|
| LT |
TRD
|
|
| notation |
CDR0000752177
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
insulin lispro
|
|
| tui |
T125 T116 T121
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