1-methyl-2',6'-pipecoloxylidide hydrochloride (SY), (1-methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride

Carbocaine

Polocaine

The hydrochloride salt form of mepivacaine, an amide-type local anesthetic agent. At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47602" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47602" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000751573

1-methyl-2',6'-pipecoloxylidide hydrochloride (SY), (1-methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride

Carbocaine

Polocaine

96-88-8

C1736247

C0700542

C0006987

2013-08-05

2013-08-05

The hydrochloride salt form of mepivacaine, an amide-type local anesthetic agent. At the injection site, mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47602" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47602" NCI Thesaurus)

TRD

C47602

CDR0000751573

Drug/agent

mepivacaine hydrochloride

T109

T121