Preferred Name | acenocoumarol | |
Synonyms |
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Definitions |
A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C75152" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C75152" NCI Thesaurus) |
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ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000750633 |
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CAS Registry |
152-72-7 |
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cui |
C0000956 |
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DATE FIRST PUBLISHED |
2013-06-20 |
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Date last modified |
2013-06-20 |
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definition |
A 4-hydroxycoumarin derivative with anticoagulant activity. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity and thus thrombin formation. Compared to other coumarin derivatives, acenocoumarol has a short half-life. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C75152" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C75152" NCI Thesaurus) |
|
NCI ID |
C75152 |
|
notation |
CDR0000750633 |
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ORIG STY |
Drug/agent |
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prefLabel |
acenocoumarol |
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tui |
T109 T121 |