chlorhexidine gluconate

Peridex

The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47974" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000747732

Peridex

18472-51-0

C0728727

C0055361

2013-03-14

2015-10-06

The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47974" NCI Thesaurus)

TRD

C47974

CDR0000747732

Drug/agent

chlorhexidine gluconate

T109

T121