Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

mebendazole
Synonyms

Ovex

(5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester

R 17635

Vermox

Methyl 5-benzoyl benzimidazole-2-carbamate

Definitions

A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47595" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000743306

altLabel

Ovex

(5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester

R 17635

Vermox

Methyl 5-benzoyl benzimidazole-2-carbamate

CAS Registry

31431-39-7

cui

C0699951

C0069693

C0025023

C2949739

DATE FIRST PUBLISHED

2012-11-27

Date last modified

2016-01-12

definition

A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47595" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47595" NCI Thesaurus)

LT

TRD

NCI ID

C47595

notation

CDR0000743306

NSC Code

184849

ORIG STY

Drug/agent

prefLabel

mebendazole

tui

T109

T131

T121

Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/202972 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/16321007 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387311004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/x02uF RCD CUI
http://purl.bioontology.org/ontology/MESH/D008463 MESH CUI
http://purl.bioontology.org/ontology/MESH/C005285 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/16321007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-23143 SNMI CUI
http://purl.bioontology.org/ontology/ATC/P02CA01 ATC CUI
http://purl.bioontology.org/ontology/RCD/eq1.. RCD CUI
http://purl.bioontology.org/ontology/SNMI/C-56A10 SNMI CUI
http://purl.bioontology.org/ontology/SCTSPA/56059005 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4019270 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/6672 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/002987 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006419 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D008463 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/387311004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147469 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/56059005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D008463 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_6704 DRON LOOM
http://stirdf.jst.go.jp/id/200907075644802442 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6704 NIFSTD LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387311004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/P02CA01 ATC LOOM
https://go.drugbank.com/drugs/DB00643 MDM LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Mebendazole SEPON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025023 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7825 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.251.415 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-56A10 SNMI LOOM
http://purl.jp/bio/4/id/200906083947474749 IOBC LOOM
http://www.drugbank.ca/drugs/DB00643 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008463 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C47595 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4019270 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/6672 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47595 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/002987 NDDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016346 PMAPP-PMO LOOM
http://www.co-ode.org/ontologies/galen#Mebendazole GALEN LOOM
http://purl.obolibrary.org/obo/MESH_D008463 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0009529 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147469 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.103.600 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D008463 MESH LOOM