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Physician Data Query
| Preferred Name | eplerenone | |
| Synonyms |
9,11alpha-epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester Inspra |
|
| Definitions |
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47513" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47513" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000741940 |
|
| altLabel |
9,11alpha-epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester Inspra
|
|
| CAS Registry |
107724-20-9
|
|
| cui |
C1144054 C0961485
|
|
| DATE FIRST PUBLISHED |
2012-10-23
|
|
| Date last modified |
2012-10-22
|
|
| definition |
A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47513" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47513" NCI Thesaurus)
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|
| LT |
TRD
|
|
| NCI ID |
C47513
|
|
| notation |
CDR0000741940
|
|
| ORIG STY |
Drug/agent
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|
| prefLabel |
eplerenone
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|
| tui |
T109 T121
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