Xylonest

L-67

2-(propylamino)-o-propionotoluidide hydrochloride

Citanest

The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48012" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48012" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000709375

Xylonest

L-67

2-(propylamino)-o-propionotoluidide hydrochloride

Citanest

1786-81-8

C2936920

C0591261

C4721401

C0008846

2011-08-17

2017-03-30

The hydrochloride salt form of prilocaine, an intermediate-acting local anesthetic of the amide type chemically related to lidocaine. Prilocaine hydrochloride binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. This leads to a stabilization of the neuronal membrane and inhibits depolarization and results in a reversible blockage of nerve impulse generation and propagation along nerve fibres and subsequent reversible loss of sensation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48012" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48012" NCI Thesaurus)

TRD

C48012

CDR0000709375

Drug/agent

prilocaine hydrochloride

T109

T121