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Physician Data Query
| Preferred Name | rivaroxaban | |
| Synonyms |
5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide Xarelto BAY 59-7939 |
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| Definitions |
An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77995" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C77995" NCI Thesaurus) |
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| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000701565 |
|
| altLabel |
5-chloro-N-[[2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide Xarelto BAY 59-7939
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| CAS Registry |
366789-02-8
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|
| cui |
C3159309 C1611967 C1739768
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| DATE FIRST PUBLISHED |
2011-06-02
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| Date last modified |
2011-06-01
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|
| definition |
An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77995" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C77995" NCI Thesaurus)
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| LT |
TRD
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| NCI ID |
C77995
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|
| notation |
CDR0000701565
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| ORIG STY |
Drug/agent
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|
| prefLabel |
rivaroxaban
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| tui |
T109 T121
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