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Physician Data Query
| Preferred Name | tolbutamide | |
| Synonyms |
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| Definitions |
A first-generation sulfonylurea with hypoglycemic activity. Tolbutamide binds to and blocks adenosine triphosphate (ATP)-sensitive potassium channels on the beta cell membrane of the pancreatic islet tissues. This leads to potassium efflux, which results in depolarization, calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis. In addition, tolbutamide may increase the number and affinity of cell surface insulin receptors, thereby enhancing the peripheral response to insulin. Tolbutamide is a CYP2C9 substrate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66610" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66610" NCI Thesaurus) |
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| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000684270 |
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| CAS Registry |
64-77-7
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| cui |
C0040374
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| DATE FIRST PUBLISHED |
2010-08-24
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| Date last modified |
2011-02-22
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| definition |
A first-generation sulfonylurea with hypoglycemic activity. Tolbutamide binds to and blocks adenosine triphosphate (ATP)-sensitive potassium channels on the beta cell membrane of the pancreatic islet tissues. This leads to potassium efflux, which results in depolarization, calcium influx, calcium-calmodulin binding, kinase activation, and release of insulin-containing granules by exocytosis. In addition, tolbutamide may increase the number and affinity of cell surface insulin receptors, thereby enhancing the peripheral response to insulin. Tolbutamide is a CYP2C9 substrate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66610" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66610" NCI Thesaurus)
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| NCI ID |
C66610
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| notation |
CDR0000684270
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| ORIG STY |
Drug/agent
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| prefLabel |
tolbutamide
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| tui |
T109 T121
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