Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

trientine hydrochloride
Synonyms

TETA

trien

spyrine

N,N'-bis(2-aminoethyl)ethane-1,2-diamine

triethylenetetramine dihydrochloride

Definitions

The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61987" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000683662

altLabel

TETA

trien

spyrine

N,N'-bis(2-aminoethyl)ethane-1,2-diamine

triethylenetetramine dihydrochloride

CAS Registry

112-24-3

cui

C0770325

C4733222

DATE FIRST PUBLISHED

2010-08-13

Date last modified

2010-12-28

definition

The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61987" NCI Thesaurus)

LT

TRD

NCI ID

C61987

notation

CDR0000683662

ORIG STY

Drug/agent

prefLabel

trientine hydrochloride

tui

T109

T121

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