loading...| Preferred Name |
trientine hydrochloride |
|
| Synonyms |
TETA |
|
| Definitions |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61987" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000683662 |
|
| altLabel |
TETA trien spyrine N,N'-bis(2-aminoethyl)ethane-1,2-diamine triethylenetetramine dihydrochloride |
|
| CAS Registry |
112-24-3 |
|
| cui |
C0770325 C4733222 |
|
| DATE FIRST PUBLISHED |
2010-08-13 |
|
| Date last modified |
2010-12-28 |
|
| definition |
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the body; the excess copper is subsequently removed from the body through the kidneys. As Cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 (SOD1), depletion of copper may inhibit the activation of signal transduction pathways required for cellular proliferation and angiogenesis. In addition, trientine may inhibit copper-induced secretion of interleukin-8 (IL-8). Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61987" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61987" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61987 |
|
| notation |
CDR0000683662 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
trientine hydrochloride |
|
| tui |
T109 T121 |