Link to this page
Physician Data Query
| Preferred Name | limonene | |
| Synonyms |
1-methyl-4-prop-1-en-2-yl-cyclohexene 4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene |
|
| Definitions |
An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000664042 |
|
| altLabel |
1-methyl-4-prop-1-en-2-yl-cyclohexene 4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene
|
|
| cui |
C0064992
|
|
| DATE FIRST PUBLISHED |
2010-01-19
|
|
| Date last modified |
2010-09-20
|
|
| definition |
An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68543" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68543" NCI Thesaurus)
|
|
| NCI ID |
C68543
|
|
| notation |
CDR0000664042
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
limonene
|
|
| tui |
T109 T121
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |