Link to this page
Physician Data Query
Last uploaded:
August 27, 2019
Jump to:
Preferred Name | rosuvastatin calcium | |
Synonyms |
Crestor |
|
Definitions |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61933" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61933" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000654583 |
|
altLabel |
Crestor
|
|
CAS Registry |
147098-20-2
|
|
cui |
C1101751 C1098080
|
|
DATE FIRST PUBLISHED |
2009-09-08
|
|
Date last modified |
2015-09-11
|
|
definition |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61933" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61933" NCI Thesaurus)
|
|
LT |
TRD
|
|
NCI ID |
C61933
|
|
notation |
CDR0000654583
|
|
ORIG STY |
Drug/agent
|
|
prefLabel |
rosuvastatin calcium
|
|
tui |
T109 T121
|
Add comment
Delete | Subject | Author | Type | Created |
---|---|---|---|---|
No notes to display |
Create mapping