loading...| Preferred Name |
rosuvastatin calcium |
|
| Synonyms |
Crestor |
|
| Definitions |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61933" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61933" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000654583 |
|
| altLabel |
Crestor |
|
| CAS Registry |
147098-20-2 |
|
| cui |
C1101751 C1098080 |
|
| DATE FIRST PUBLISHED |
2009-09-08 |
|
| Date last modified |
2015-09-11 |
|
| definition |
The calcium salt form of rosuvastatin, a statin with antilipidemic activity. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61933" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61933" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C61933 |
|
| notation |
CDR0000654583 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
rosuvastatin calcium |
|
| tui |
T109 T121 |