loading...| Preferred Name | glasdegib | |
| Synonyms |
PF-04449913 Hedgehog Inhibitor PF-04449913 |
|
| Definitions |
An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Glasdegib appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84862" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84862" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000652940 |
|
| altLabel |
PF-04449913 Hedgehog Inhibitor PF-04449913 |
|
| cui |
C4519273 C3886640 |
|
| DATE FIRST PUBLISHED |
2009-08-19 |
|
| Date last modified |
2018-08-06 |
|
| definition |
An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Glasdegib appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84862" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C84862" NCI Thesaurus) |
|
| NCI ID |
C84862 |
|
| notation |
CDR0000652940 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
glasdegib |
|
| tui |
T109 T121 |