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Physician Data Query
| Preferred Name | sonidegib | |
| Synonyms |
erismodegib LDE-225 LDE225 smoothened antagonist LDE225 Odomzo |
|
| Definitions |
An orally bioavailable small-molecule smoothened (Smo) antagonist with potential antineoplastic activity. Sonidegib selectively binds to the hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82385" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82385" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000641974 |
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| altLabel |
erismodegib LDE-225 LDE225 smoothened antagonist LDE225 Odomzo
|
|
| cui |
C4046853 C3886731 C2830069
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|
| DATE FIRST PUBLISHED |
2009-04-29
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| Date last modified |
2015-07-27
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|
| definition |
An orally bioavailable small-molecule smoothened (Smo) antagonist with potential antineoplastic activity. Sonidegib selectively binds to the hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82385" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C82385" NCI Thesaurus)
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| LT |
TRD
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| NCI ID |
C82385
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|
| notation |
CDR0000641974
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| ORIG STY |
Drug/agent
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|
| prefLabel |
sonidegib
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|
| tui |
T109 T121
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