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Physician Data Query
| Preferred Name | cefazolin sodium | |
| Synonyms |
Kefzol (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, sodium salt Ancef SKF 41558 |
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| Definitions |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000640180 |
|
| altLabel |
Kefzol (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, sodium salt Ancef SKF 41558
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| CAS Registry |
27164-46-1
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|
| cui |
C0700926 C0700925 C2720180 C0700526
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| DATE FIRST PUBLISHED |
2009-04-06
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| Date last modified |
2009-04-06
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|
| definition |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47968" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47968" NCI Thesaurus)
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|
| LT |
TRD
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| NCI ID |
C47968
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|
| notation |
CDR0000640180
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| NSC Code |
291561
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| ORIG STY |
Drug/agent
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| prefLabel |
cefazolin sodium
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| tui |
T109 T195
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