loading...| Preferred Name | light chain deposition disease | |
| Synonyms |
Bence Jones Myeloma Light Chain Disease |
|
| Definitions |
A condition in which plasma cells secrete immunoglobulin light chains of only one type, kappa or lambda. Light chain deposition disease is often associated with multiple myeloma or lymphoproliferative disease, but as many as 50% of patients have no evidence of neoplastic plasma cell proliferation. Light chains excreted in the urine are known as Bence Jones protein. Amyloidosis and severe renal failure occur more frequently than in multiple myeloma. Also known as Bence Jones myeloma. L-chain disease, L-chain myeloma, and LCDD. --2004 Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7727" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C7727" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000618311 |
|
| altLabel |
Bence Jones Myeloma Light Chain Disease |
|
| cui |
C0238239 |
|
| DATE FIRST PUBLISHED |
2008-10-23 |
|
| Date last modified |
2017-03-30 |
|
| definition |
A condition in which plasma cells secrete immunoglobulin light chains of only one type, kappa or lambda. Light chain deposition disease is often associated with multiple myeloma or lymphoproliferative disease, but as many as 50% of patients have no evidence of neoplastic plasma cell proliferation. Light chains excreted in the urine are known as Bence Jones protein. Amyloidosis and severe renal failure occur more frequently than in multiple myeloma. Also known as Bence Jones myeloma. L-chain disease, L-chain myeloma, and LCDD. --2004 Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7727" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C7727" NCI Thesaurus) |
|
| MENU PARENT |
multiple myeloma and other plasma cell neoplasms |
|
| MENU TYPE |
Clinical Trials--CancerType |
|
| NCI ID |
C7727 |
|
| notation |
CDR0000618311 |
|
| ORIG STY |
Cancer stage |
|
| prefLabel |
light chain deposition disease |
|
| tui |
T191 |
|
| subClassOf |