Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

artesunate
Synonyms

ART

Definitions

A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-shistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated form the plant Artemisia annua. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73005" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000617258

altLabel

ART

cui

C0052432

DATE FIRST PUBLISHED

2008-10-10

Date last modified

2009-06-05

definition

A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-shistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated form the plant Artemisia annua. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C73005" NCI Thesaurus)

NCI ID

C73005

notation

CDR0000617258

ORIG STY

Drug/agent

prefLabel

artesunate

tui

T109

T121

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000179045 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000171767 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4025235 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/18346 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/432555000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000077332 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/432410005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/432555000 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/432410005 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077332 MSHFRE CUI
http://purl.bioontology.org/ontology/ATC/P01BE03 ATC CUI
http://purl.bioontology.org/ontology/NDDF/009953 NDDF CUI
http://purl.obolibrary.org/obo/CHEBI_63918 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171767 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4025235 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/18346 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/D000077332 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C039726 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0052432 OCHV LOOM
https://go.drugbank.com/drugs/DB09274 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/432410005 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73005 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13525 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026683 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/SCDO_0000073 SCDO LOOM
http://purl.bioontology.org/ontology/ATC/P01BE03 ATC LOOM
http://purl.obolibrary.org/obo/NCIT_C73005 BERO LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000246 IDOMAL LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_63918 EFO LOOM
http://purl.bioontology.org/ontology/NDDF/009953 NDDF LOOM