Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

copper gluconate
Synonyms

cupric gluconate
Definitions

The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80050" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80050" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000614606
altLabel

cupric gluconate
cui

C0982097

C0009975
DATE FIRST PUBLISHED

2008-09-09
Date last modified

2009-05-29
definition

The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80050" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C80050" NCI Thesaurus)
NCI ID

C80050
notation

CDR0000614606
ORIG STY

Drug/agent
prefLabel

copper gluconate
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000022430 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4020096 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017698 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D005942 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/2839 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/005112 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/442252001 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/442252001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D005942 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178906 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148097 NDFRT CUI
http://purl.obolibrary.org/obo/CHEBI_31431 DRON LOOM
http://purl.bioontology.org/ontology/VANDF/4020096 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/2839 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C80050 BERO LOOM
https://go.drugbank.com/drugs/DB11246 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/442252001 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_31431 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31431 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31431 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31431 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31431 DDSS LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80050 NCIT LOOM
http://id.nlm.nih.gov/mesh/D005942 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148097 NDFRT LOOM