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Physician Data Query
| Preferred Name | riluzole | |
| Synonyms |
2-amino-6-(trifluoromethoxy)benzothiazole Rilutek |
|
| Definitions |
A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors.In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47704" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47704" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000594943 |
|
| altLabel |
2-amino-6-(trifluoromethoxy)benzothiazole Rilutek
|
|
| cui |
C0678179 C0073379
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|
| DATE FIRST PUBLISHED |
2008-04-23
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|
| Date last modified |
2009-01-13
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|
| definition |
A benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors.In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47704" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47704" NCI Thesaurus)
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|
| LT |
TRD
|
|
| NCI ID |
C47704
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|
| notation |
CDR0000594943
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| ORIG STY |
Drug/agent
|
|
| prefLabel |
riluzole
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|
| tui |
T109 T121
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