vismodegib

Erivedge

An orally bioavailable small molecule with potential antineoplastic activity. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74038" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C74038" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000586417

Erivedge

2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide

Hedgehog antagonist GDC-0449

GDC-0449

C2348949

C3265872

C2987716

2008-01-29

2012-01-30

An orally bioavailable small molecule with potential antineoplastic activity. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74038" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C74038" NCI Thesaurus)

TRD

C74038

CDR0000586417

Drug/agent

vismodegib

T109

T121