Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

cefmetazole sodium
Synonyms
Definitions

The sodium salt of the second-generation, semi-synthetic, beta-lactam cephalosporin cefmetazole with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs) and prevents the crosslinking of peptidoglycan, which may result in the inhibition of cell wall synthesis, the loss of cell wall integrity, and bacterial cell wall rupture. PBPs are transpeptidases that are responsible for peptidoglycan crosslinking. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65298" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000564415
CAS Registry

56796-39-5

56796-20-4
cui

C0700470
DATE FIRST PUBLISHED

2007-08-23
Date last modified

2010-03-28
definition

The sodium salt of the second-generation, semi-synthetic, beta-lactam cephalosporin cefmetazole with antibacterial activity. Cefmetazole binds to penicillin-binding proteins (PBPs) and prevents the crosslinking of peptidoglycan, which may result in the inhibition of cell wall synthesis, the loss of cell wall integrity, and bacterial cell wall rupture. PBPs are transpeptidases that are responsible for peptidoglycan crosslinking. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65298" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65298" NCI Thesaurus)
NCI ID

C65298
notation

CDR0000564415
ORIG STY

Drug/agent
prefLabel

cefmetazole sodium
tui

T109

T195
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