loading...| Preferred Name |
olaparib |
|
| Synonyms |
PARP inhibitor AZD2281 AZD2281 KU-0059436 Lynparza |
|
| Definitions |
A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance.PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71721" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71721" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000560191 |
|
| altLabel |
PARP inhibitor AZD2281 AZD2281 KU-0059436 Lynparza |
|
| cui |
C2316164 C3872110 C4721943 C2347419 |
|
| DATE FIRST PUBLISHED |
2007-07-24 |
|
| Date last modified |
2014-12-22 |
|
| definition |
A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance.PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71721" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71721" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C71721 |
|
| notation |
CDR0000560191 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
olaparib |
|
| tui |
T109 T121 |