loading...| Preferred Name | nifurtimox | |
| Synonyms |
Lampit |
|
| Definitions |
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71734" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71734" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000558911 |
|
| altLabel |
Lampit |
|
| cui |
C0877960 C0028073 |
|
| DATE FIRST PUBLISHED |
2007-07-06 |
|
| Date last modified |
2008-05-06 |
|
| definition |
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71734" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C71734" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C71734 |
|
| notation |
CDR0000558911 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
nifurtimox |
|
| tui |
T109 T121 |