loading...| Preferred Name |
abiraterone acetate |
|
| Synonyms |
CB7630 |
|
| Definitions |
An orally active acetate salt of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68845" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000552704 |
|
| altLabel |
CB7630 Zytiga |
|
| cui |
C0289344 C2607886 C3153774 |
|
| DATE FIRST PUBLISHED |
2007-05-23 |
|
| Date last modified |
2011-05-12 |
|
| definition |
An orally active acetate salt of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68845" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C68845" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C68845 |
|
| notation |
CDR0000552704 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
abiraterone acetate |
|
| tui |
T109 T121 |