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Last uploaded:
August 28, 2024
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| Preferred Name | sodium phenylbutyrate | |
| Synonyms |
sodium 4-phenylbutyrate Buphenyl |
|
| Definitions |
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1440" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1440" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000536018 |
|
| altLabel |
sodium 4-phenylbutyrate Buphenyl
|
|
| cui |
C0719042 C0718066
|
|
| DATE FIRST PUBLISHED |
2007-02-12
|
|
| Date last modified |
2008-04-23
|
|
| definition |
The sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1440" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1440" NCI Thesaurus)
|
|
| LT |
TRD
|
|
| NCI ID |
C1440
|
|
| notation |
CDR0000536018
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
sodium phenylbutyrate
|
|
| tui |
T109 T121
|
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