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Physician Data Query
| Preferred Name | magnesium citrate | |
| Synonyms |
Citramag Citroma citrate of magnesia |
|
| Definitions |
The citrate salt of the element magnesium with cathartic activity. The cathartic action of magnesium cations appears to result, in part, from osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate intestinal secretion via prostglandin- and cyclic GMP-dependent mechanisms while PAF produces significant stimulation of colonic secretion and gastrointestinal motility. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29241" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29241" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000480467 |
|
| altLabel |
Citramag Citroma citrate of magnesia
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|
| cui |
C0719355 C0591262 C0126774
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| DATE FIRST PUBLISHED |
2006-04-14
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|
| Date last modified |
2008-03-05
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|
| definition |
The citrate salt of the element magnesium with cathartic activity. The cathartic action of magnesium cations appears to result, in part, from osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate intestinal secretion via prostglandin- and cyclic GMP-dependent mechanisms while PAF produces significant stimulation of colonic secretion and gastrointestinal motility. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29241" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29241" NCI Thesaurus)
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|
| LT |
TRD
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| NCI ID |
C29241
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|
| notation |
CDR0000480467
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| ORIG STY |
Drug/agent
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|
| prefLabel |
magnesium citrate
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|
| tui |
T109 T121
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