loading...| Preferred Name | etoricoxib | |
| Synonyms |
5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) Pyridine L-791456 MK-0663 Arcoxia |
|
| Definitions |
A synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic ,and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52188" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52188" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000462092 |
|
| altLabel |
5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) Pyridine L-791456 MK-0663 Arcoxia |
|
| cui |
C1130504 C1530229 C0972314 C1097007 |
|
| DATE FIRST PUBLISHED |
2006-01-25 |
|
| Date last modified |
2006-08-02 |
|
| definition |
A synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic ,and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52188" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C52188" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C52188 |
|
| notation |
CDR0000462092 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
etoricoxib |
|
| tui |
T109 T121 |