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Physician Data Query
| Preferred Name | zolpidem tartrate | |
| Synonyms |
ZPD Ambien |
|
| Definitions |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29553" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29553" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000370808 |
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| altLabel |
ZPD Ambien
|
|
| Component of | ||
| cui |
C0724725 C0487782 C0078839
|
|
| DATE FIRST PUBLISHED |
2004-05-28
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|
| Date last modified |
2008-02-04
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|
| definition |
The tartrate salt of an imidazopyridine with non-benzodiazepine benzodiazepine-receptor agonist and sedative-hypnotic activities. Zolpidem binds selectively to the alpha 1 subunit of the omega-1 (BZ1) receptor of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening neuronal chloride channels, hyperpolarizing neuronal cell membranes, and inhibiting neuronal firing. In contrast, benzodiazepines non-selectively bind to and activate all omega receptor subtypes, exhibiting anticonvulsant and myorelaxant activities in addition to a sedative-hypnotic activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29553" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C29553" NCI Thesaurus)
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|
| LT |
TRD
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| NCI ID |
C29553
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|
| notation |
CDR0000370808
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|
| ORIG STY |
Drug/agent
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|
| prefLabel |
zolpidem tartrate
|
|
| tui |
T109 T121
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