Physician Data Query

Last uploaded: August 27, 2019
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Preferred Name

posaconazole
Synonyms

Noxafil

SCH 56592
Definitions

A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61500" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61500" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000361793
altLabel

Noxafil

SCH 56592
cui

C0936148

C0529792

C1174778
DATE FIRST PUBLISHED

2004-03-24
Date last modified

2006-10-11
definition

A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis. Compared to other azole antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61500" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61500" NCI Thesaurus)
LT

TRD
NCI ID

C61500
notation

CDR0000361793
ORIG STY

Drug/agent
prefLabel

posaconazole
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/SCTSPA/420282006 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/C101425 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/356772 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/420282006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP71165-2 LOINC CUI
http://purl.bioontology.org/ontology/VANDF/4025699 VANDF CUI
http://purl.bioontology.org/ontology/NDDF/011210 NDDF CUI
http://purl.bioontology.org/ontology/RXNORM/282446 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/421747003 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179745 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C101425 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000176062 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/J02AC04 ATC CUI
http://purl.bioontology.org/ontology/LNC/MTHU030157 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/421747003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/C101425 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_64355 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 DRON LOOM
http://purl.obolibrary.org/obo/ARO_3007513 ARO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026041 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP71165-2 LOINC LOOM
http://purl.bioontology.org/ontology/CPT/80187 CPT LOOM
https://go.drugbank.com/drugs/DB01263 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4025699 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/011210 NDDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61500 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/282446 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_64355 PHIPO LOOM
http://purl.obolibrary.org/obo/DRON_00018916 ODNAE LOOM
http://purl.bioontology.org/ontology/MESH/C101425 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000176062 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/J02AC04 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU030157 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C101425 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/421747003 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/NCIT_C61500 BERO LOOM