Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

etanercept
Synonyms

Enbrel

TNFR:Fc

Tumor Necrosis Factor Receptor IgG Chimera

ETN
Definitions

A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2381" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2381" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000257809
altLabel

Enbrel

TNFR:Fc

Tumor Necrosis Factor Receptor IgG Chimera

ETN
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000437893

http://purl.bioontology.org/ontology/PDQ/CDR0000437892

http://purl.bioontology.org/ontology/PDQ/CDR0000383247
cui

C0717758

C0720193
Date last modified

2006-08-02
definition

A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2381" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2381" NCI Thesaurus)
Legacy PDQ ID

11464
LT

TRD
NCI ID

C2381
notation

CDR0000257809
ORIG STY

Drug/agent
prefLabel

etanercept
tui

T116

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000068800 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/216891 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148590 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/LP220257-2 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387045004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/007673 NDDF CUI
http://purl.bioontology.org/ontology/RXNORM/214555 RXNORM CUI
http://purl.bioontology.org/ontology/ATC/L04AB01 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/387045004 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000191929 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/MTHU054569 LOINC CUI
http://purl.bioontology.org/ontology/SCTSPA/118259007 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4021136 VANDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/118259007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068800 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D000068800 MESH CUI
http://purl.bioontology.org/ontology/MSHFRE/D000068800 MSHFRE CUI
http://purl.obolibrary.org/obo/CHEBI_4875 CHEBI LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00476 COID LOOM
http://purl.obolibrary.org/obo/NCIT_C2381 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D000068800 MESH LOOM
http://www.drugbank.ca/drugs/DB00005 FTC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148590 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP220257-2 LOINC LOOM
http://purl.obolibrary.org/obo/dinto_DB00005 DINTO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387045004 SNOMEDCT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022091 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDDF/007673 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#45174 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/214555 RXNORM LOOM
http://doe-generated-ontology.com/OntoAD#C0717758 ONTOAD LOOM
http://purl.bioontology.org/ontology/ATC/L04AB01 ATC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0717758 HFO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0717758 OCHV LOOM
https://go.drugbank.com/drugs/DB00005 MDM LOOM
http://purl.obolibrary.org/obo/MESH_D000068800 BERO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2381 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU054569 LOINC LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00023 OCIMIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_4875 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4875 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4875 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4875 DDSS LOOM
http://bmi.utah.edu/ontologies/peontology/C0717758 RAO LOOM
http://purl.jp/bio/4/id/200906056230071693 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4021136 VANDF LOOM
http://purl.obolibrary.org/obo/OMIT_0001329 OMIT LOOM