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| Preferred Name | teniposide | |
| Synonyms |
PTG [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one Vumon Thenvlidene-Lignan-P Vehem Thenylidene-Lignan-P VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside) VM26 4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside EPT |
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| Definitions |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C857" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C857" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043671 |
|
| altLabel |
PTG [5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one Vumon Thenvlidene-Lignan-P Vehem Thenylidene-Lignan-P VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside) VM26 4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside EPT
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| CAS Registry |
29767-20-2
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| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041034 http://purl.bioontology.org/ontology/PDQ/CDR0000040807 http://purl.bioontology.org/ontology/PDQ/CDR0000039461 http://purl.bioontology.org/ontology/PDQ/CDR0000039037 http://purl.bioontology.org/ontology/PDQ/CDR0000041831 http://purl.bioontology.org/ontology/PDQ/CDR0000041501 http://purl.bioontology.org/ontology/PDQ/CDR0000040937 http://purl.bioontology.org/ontology/PDQ/CDR0000041040 http://purl.bioontology.org/ontology/PDQ/CDR0000041737 http://purl.bioontology.org/ontology/PDQ/CDR0000039776 http://purl.bioontology.org/ontology/PDQ/CDR0000039780 http://purl.bioontology.org/ontology/PDQ/CDR0000039589 http://purl.bioontology.org/ontology/PDQ/CDR0000040254 http://purl.bioontology.org/ontology/PDQ/CDR0000038868 http://purl.bioontology.org/ontology/PDQ/CDR0000039462 http://purl.bioontology.org/ontology/PDQ/CDR0000041934 http://purl.bioontology.org/ontology/PDQ/CDR0000040283 http://purl.bioontology.org/ontology/PDQ/CDR0000037875 http://purl.bioontology.org/ontology/PDQ/CDR0000040930 http://purl.bioontology.org/ontology/PDQ/CDR0000040663 http://purl.bioontology.org/ontology/PDQ/CDR0000038630 http://purl.bioontology.org/ontology/PDQ/CDR0000041007 http://purl.bioontology.org/ontology/PDQ/CDR0000041833 http://purl.bioontology.org/ontology/PDQ/CDR0000038930 http://purl.bioontology.org/ontology/PDQ/CDR0000039036 http://purl.bioontology.org/ontology/PDQ/CDR0000040901 http://purl.bioontology.org/ontology/PDQ/CDR0000040155 http://purl.bioontology.org/ontology/PDQ/CDR0000039513 |
|
| cui |
C0039512 C0728981 C0733482 C0733481
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| Date last modified |
2006-12-28
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|
| definition |
A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C857" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C857" NCI Thesaurus)
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| IND Code |
9336
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| Legacy PDQ ID |
917
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| LT |
TRD
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| NCI ID |
C857
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|
| notation |
CDR0000043671
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|
| NSC Code |
122819
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| ORIG STY |
Drug/agent
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|
| prefLabel |
teniposide
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|
| tui |
T109 T121
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