loading...| Preferred Name |
megestrol acetate |
|
| Synonyms |
6-dehydro-6-methyl-17.alpha.-acetoxyprogesterone |
|
| Definitions |
The acetate salt of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes. Megestrol's antineoplastic activity against estrogen-responsive tumors may be due, in part, to the suppression of pituitary gonadotrophin production and the resultant decrease in ovarian estrogen secretion; interference with the estrogen receptor complex in its interaction with genes and; as part of the progesterone receptor complex, direct interaction with the genome and downregulation of specific estrogen-responsive genes. This agent may also directly kill tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1156" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1156" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043435 |
|
| altLabel |
6-dehydro-6-methyl-17.alpha.-acetoxyprogesterone 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate Maygace 6-dehydro-6-methyl-17 alpha-acetoxyprogesterone BDH 1298 ovaban Megestat BDH-1298 6-methyl-6-dehydro-17.alpha.-acetoxyprogesterone (9beta,10alpha)-17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione Niagestin SC-10363 17 alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione 6-methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione acetate Megestil pallace |
|
| CAS Registry |
595-33-5 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038570 http://purl.bioontology.org/ontology/PDQ/CDR0000041584 http://purl.bioontology.org/ontology/PDQ/CDR0000042532 |
|
| cui |
C1513083 C1513086 C1524041 C1524040 C0733353 C1328258 C0065879 C1513085 C0700004 |
|
| Date last modified |
2017-12-13 |
|
| definition |
The acetate salt of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Mimicking the action of progesterone, megestrol binds to and activates nuclear progesterone receptors (PRs) in the reproductive system and pituitary; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes. Megestrol's antineoplastic activity against estrogen-responsive tumors may be due, in part, to the suppression of pituitary gonadotrophin production and the resultant decrease in ovarian estrogen secretion; interference with the estrogen receptor complex in its interaction with genes and; as part of the progesterone receptor complex, direct interaction with the genome and downregulation of specific estrogen-responsive genes. This agent may also directly kill tumor cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1156" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1156" NCI Thesaurus) |
|
| Legacy PDQ ID |
855 |
|
| LT |
TRD |
|
| NCI ID |
C1156 |
|
| notation |
CDR0000043435 |
|
| NSC Code |
71423 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
megestrol acetate |
|
| tui |
T125 T109 T121 |