loading...| Preferred Name |
lepirudin |
|
| Synonyms |
Recombinant Hirudin |
|
| Definitions |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1839" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1839" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043356 |
|
| altLabel |
Recombinant Hirudin Refludan |
|
| cui |
C0772394 C0661608 |
|
| Date last modified |
2006-12-13 |
|
| definition |
A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1839" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1839" NCI Thesaurus) |
|
| Legacy PDQ ID |
7902 |
|
| LT |
TRD |
|
| NCI ID |
C1839 |
|
| notation |
CDR0000043356 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
lepirudin |
|
| tui |
T109 T116 T121 |