Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

lepirudin
Synonyms

Recombinant Hirudin

Refludan
Definitions

A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1839" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1839" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000043356
altLabel

Recombinant Hirudin

Refludan
cui

C0772394

C0661608
Date last modified

2006-12-13
definition

A yeast cell-derived recombinant polypeptide related to the naturally occurring, leech-derived anticoagulant hirudin. Lepirudin directly binds to and inactivates thrombin, producing dose-dependent increases in the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The mechanism of action of this agent is independent of antithrombin III and is not inhibited by platelet factor 4. Natural hirudin, a family of highly homologous isopolypeptides, is produced in trace amounts by the leech Hirudo medicinalis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1839" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1839" NCI Thesaurus)
Legacy PDQ ID

7902
LT

TRD
NCI ID

C1839
notation

CDR0000043356
ORIG STY

Drug/agent
prefLabel

lepirudin
tui

T109

T116

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/237057 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x04pi RCD CUI
http://purl.bioontology.org/ontology/NDDF/007520 NDDF CUI
http://purl.bioontology.org/ontology/LNC/LP171615-0 LOINC CUI
http://purl.bioontology.org/ontology/ATC/B01AE02 ATC CUI
http://purl.bioontology.org/ontology/SCTSPA/386955005 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/108995001 SCTSPA CUI
http://purl.bioontology.org/ontology/VANDF/4021096 VANDF CUI
http://purl.bioontology.org/ontology/NDDF/007521 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148552 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005006 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C083544 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108995001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386955005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/brA.. RCD CUI
http://purl.bioontology.org/ontology/MESH/C083544 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_142437 DRON LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48816 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C083544 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_142437 DDSS LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025401 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/237057 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/007520 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP171615-0 LOINC LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02637 MIO LOOM
http://purl.bioontology.org/ontology/ATC/B01AE02 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0772394 OCHV LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Lepirudin SEPON LOOM
http://purl.bioontology.org/ontology/VANDF/4021096 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00001 DINTO LOOM
https://go.drugbank.com/drugs/DB00001 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148552 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C1839 BERO LOOM
http://www.co-ode.org/ontologies/galen#Lepirudin GALEN LOOM
http://www.drugbank.ca/drugs/DB00001 FTC LOOM
http://purl.jp/bio/4/id/201306034051700490 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/C083544 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1839 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386955005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/brA.. RCD LOOM