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Last uploaded: January 31, 2024

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Preferred Name	lomustine
Synonyms	Lomeblastin
Definitions	A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C617" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C617" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000043065
altLabel	Lomeblastin 1-nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl- Lucostine CCNU Gleostine Lomustinum Belustine RB-1509 chloroethylcyclo-hexylnitrosourea N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea Cecenu Belustin Prava chloroethylcyclohexylnitrosourea Lucostin Citostal WR-139017 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
CAS Registry	13010-47-4
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000040948 http://purl.bioontology.org/ontology/PDQ/CDR0000039450 http://purl.bioontology.org/ontology/PDQ/CDR0000041092 http://purl.bioontology.org/ontology/PDQ/CDR0000041997 http://purl.bioontology.org/ontology/PDQ/CDR0000041058 http://purl.bioontology.org/ontology/PDQ/CDR0000042269 http://purl.bioontology.org/ontology/PDQ/CDR0000039576 http://purl.bioontology.org/ontology/PDQ/CDR0000039402 http://purl.bioontology.org/ontology/PDQ/CDR0000039599 http://purl.bioontology.org/ontology/PDQ/CDR0000344418 http://purl.bioontology.org/ontology/PDQ/CDR0000042619 http://purl.bioontology.org/ontology/PDQ/CDR0000039355 http://purl.bioontology.org/ontology/PDQ/CDR0000039360 http://purl.bioontology.org/ontology/PDQ/CDR0000040970 http://purl.bioontology.org/ontology/PDQ/CDR0000040939 http://purl.bioontology.org/ontology/PDQ/CDR0000042611 http://purl.bioontology.org/ontology/PDQ/CDR0000039430 http://purl.bioontology.org/ontology/PDQ/CDR0000039522 http://purl.bioontology.org/ontology/PDQ/CDR0000039568 http://purl.bioontology.org/ontology/PDQ/CDR0000042268 http://purl.bioontology.org/ontology/PDQ/CDR0000039317 http://purl.bioontology.org/ontology/PDQ/CDR0000041178 http://purl.bioontology.org/ontology/PDQ/CDR0000043246 http://purl.bioontology.org/ontology/PDQ/CDR0000042083 http://purl.bioontology.org/ontology/PDQ/CDR0000038026 http://purl.bioontology.org/ontology/PDQ/CDR0000040345 http://purl.bioontology.org/ontology/PDQ/CDR0000042644 http://purl.bioontology.org/ontology/PDQ/CDR0000041879 http://purl.bioontology.org/ontology/PDQ/CDR0000039686 http://purl.bioontology.org/ontology/PDQ/CDR0000041175 http://purl.bioontology.org/ontology/PDQ/CDR0000039458 http://purl.bioontology.org/ontology/PDQ/CDR0000040420 http://purl.bioontology.org/ontology/PDQ/CDR0000039440 http://purl.bioontology.org/ontology/PDQ/CDR0000038840 http://purl.bioontology.org/ontology/PDQ/CDR0000038871 http://purl.bioontology.org/ontology/PDQ/CDR0000039695 http://purl.bioontology.org/ontology/PDQ/CDR0000042857 http://purl.bioontology.org/ontology/PDQ/CDR0000039771 http://purl.bioontology.org/ontology/PDQ/CDR0000340966 http://purl.bioontology.org/ontology/PDQ/CDR0000043520 http://purl.bioontology.org/ontology/PDQ/CDR0000043063 http://purl.bioontology.org/ontology/PDQ/CDR0000038873 http://purl.bioontology.org/ontology/PDQ/CDR0000040934 http://purl.bioontology.org/ontology/PDQ/CDR0000043106 http://purl.bioontology.org/ontology/PDQ/CDR0000039519 http://purl.bioontology.org/ontology/PDQ/CDR0000040066 http://purl.bioontology.org/ontology/PDQ/CDR0000039406 http://purl.bioontology.org/ontology/PDQ/CDR0000040455 http://purl.bioontology.org/ontology/PDQ/CDR0000039449 http://purl.bioontology.org/ontology/PDQ/CDR0000040075 http://purl.bioontology.org/ontology/PDQ/CDR0000039359 http://purl.bioontology.org/ontology/PDQ/CDR0000040245 http://purl.bioontology.org/ontology/PDQ/CDR0000039401 http://purl.bioontology.org/ontology/PDQ/CDR0000039400 http://purl.bioontology.org/ontology/PDQ/CDR0000041317 http://purl.bioontology.org/ontology/PDQ/CDR0000039645
cui	C1517934 C1517930 C1522648 C3848667 C1450043 C0699180 C1517933 C0023972 C1517929 C1517931 C0687700 C1522645
Date last modified	2016-06-07
definition	A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C617" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C617" NCI Thesaurus)
IND Code	4595
Legacy PDQ ID	742
LT	TRD
NCI ID	C617
notation	CDR0000043065
NSC Code	79037
ORIG STY	Drug/agent
prefLabel	lomustine
tui	T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RXNORM/1545771	RXNORM	CUI
http://purl.bioontology.org/ontology/MESH/D008130	MESH	CUI
http://purl.bioontology.org/ontology/MESH/D008130	MESH	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007072	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387227009	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387227009	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146475	NDFRT	CUI
http://purl.bioontology.org/ontology/SCTSPA/40999006	SCTSPA	CUI
http://purl.bioontology.org/ontology/MESH/D008130	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/6466	RXNORM	CUI
http://purl.bioontology.org/ontology/VANDF/4018138	VANDF	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/40999006	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387227009	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/1371-8111	CRISP	CUI
http://purl.bioontology.org/ontology/SNMI/C-78120	SNMI	CUI
http://purl.bioontology.org/ontology/RCD/h18..	RCD	CUI
http://purl.bioontology.org/ontology/ATC/L01AD02	ATC	CUI
http://purl.bioontology.org/ontology/MSHFRE/D008130	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDDF/002639	NDDF	CUI
http://purl.bioontology.org/ontology/MESH/D008130	MESH	CUI
http://purl.bioontology.org/ontology/RCD/x02Wy	RCD	CUI
http://purl.bioontology.org/ontology/CSP/1371-8111	CRISP	CUI
http://purl.bioontology.org/ontology/SNMI/C-78120	SNMI	CUI
http://purl.bioontology.org/ontology/RCD/h18..	RCD	CUI
http://purl.obolibrary.org/obo/CHEBI_6520	CHEBI	LOOM
https://go.drugbank.com/drugs/DB01206	MDM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387227009	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.654.692.440	RH-MESH	LOOM
http://purl.obolibrary.org/obo/dinto_DB01206	DINTO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146475	NDFRT	LOOM
http://purl.jp/bio/4/id/200906091089654710	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D008130	MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C617	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/6466	RXNORM	LOOM
http://purl.bioontology.org/ontology/VANDF/4018138	VANDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0023972	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017242	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/CSP/1371-8111	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7530	OCHV	LOOM
http://www.co-ode.org/ontologies/galen#Lomustine	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008130	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0009213	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.594.440	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	DRON	LOOM
http://purl.obolibrary.org/obo/NCIT_C617	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78120	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907076376183510	IOBC	LOOM
http://www.ifomis.org/acgt/1.0#Lomustine	ACGT-MO	LOOM
http://purl.bioontology.org/ontology/RCD/h18..	RCD	LOOM
http://purl.bioontology.org/ontology/ATC/L01AD02	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D008130	BERO	LOOM
http://purl.bioontology.org/ontology/NDDF/002639	NDDF	LOOM