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Last uploaded: January 31, 2024

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Preferred Name	carmustine
Synonyms	BCNU
Definitions	An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C349" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C349" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000043027
altLabel	BCNU Nitrumon Becenun BiCNU Carmustinum FDA 0345 1,3-bis(beta-chloroethyl)-1-nitrosourea N,N'-bis(2-chloroethyl)-N-nitrosourea Nitrourean bis(chloroethyl) nitrosourea 1,3-bis(2-chloroethyl)-1-nitrosourea SK 27702 carmustin bis-chloronitrosourea SRI 1720 WR-139021
CAS Registry	154-93-8
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000042114 http://purl.bioontology.org/ontology/PDQ/CDR0000039042 http://purl.bioontology.org/ontology/PDQ/CDR0000039403 http://purl.bioontology.org/ontology/PDQ/CDR0000039332 http://purl.bioontology.org/ontology/PDQ/CDR0000042659 http://purl.bioontology.org/ontology/PDQ/CDR0000042616 http://purl.bioontology.org/ontology/PDQ/CDR0000039648 http://purl.bioontology.org/ontology/PDQ/CDR0000041337 http://purl.bioontology.org/ontology/PDQ/CDR0000039628 http://purl.bioontology.org/ontology/PDQ/CDR0000039639 http://purl.bioontology.org/ontology/PDQ/CDR0000039709 http://purl.bioontology.org/ontology/PDQ/CDR0000041877 http://purl.bioontology.org/ontology/PDQ/CDR0000039383 http://purl.bioontology.org/ontology/PDQ/CDR0000041850 http://purl.bioontology.org/ontology/PDQ/CDR0000040787 http://purl.bioontology.org/ontology/PDQ/CDR0000041029 http://purl.bioontology.org/ontology/PDQ/CDR0000042460 http://purl.bioontology.org/ontology/PDQ/CDR0000040215 http://purl.bioontology.org/ontology/PDQ/CDR0000040923 http://purl.bioontology.org/ontology/PDQ/CDR0000041037 http://purl.bioontology.org/ontology/PDQ/CDR0000041036 http://purl.bioontology.org/ontology/PDQ/CDR0000041861 http://purl.bioontology.org/ontology/PDQ/CDR0000037955 http://purl.bioontology.org/ontology/PDQ/CDR0000041941 http://purl.bioontology.org/ontology/PDQ/CDR0000041773 http://purl.bioontology.org/ontology/PDQ/CDR0000040890 http://purl.bioontology.org/ontology/PDQ/CDR0000043112 http://purl.bioontology.org/ontology/PDQ/CDR0000043734 http://purl.bioontology.org/ontology/PDQ/CDR0000043159 http://purl.bioontology.org/ontology/PDQ/CDR0000039819 http://purl.bioontology.org/ontology/PDQ/CDR0000043359 http://purl.bioontology.org/ontology/PDQ/CDR0000042660 http://purl.bioontology.org/ontology/PDQ/CDR0000357718 http://purl.bioontology.org/ontology/PDQ/CDR0000038326 http://purl.bioontology.org/ontology/PDQ/CDR0000039379 http://purl.bioontology.org/ontology/PDQ/CDR0000041868 http://purl.bioontology.org/ontology/PDQ/CDR0000041108 http://purl.bioontology.org/ontology/PDQ/CDR0000039389 http://purl.bioontology.org/ontology/PDQ/CDR0000041130 http://purl.bioontology.org/ontology/PDQ/CDR0000043685 http://purl.bioontology.org/ontology/PDQ/CDR0000038926 http://purl.bioontology.org/ontology/PDQ/CDR0000039319 http://purl.bioontology.org/ontology/PDQ/CDR0000042294 http://purl.bioontology.org/ontology/PDQ/CDR0000039395 http://purl.bioontology.org/ontology/PDQ/CDR0000041994 http://purl.bioontology.org/ontology/PDQ/CDR0000041611 http://purl.bioontology.org/ontology/PDQ/CDR0000043074 http://purl.bioontology.org/ontology/PDQ/CDR0000041119 http://purl.bioontology.org/ontology/PDQ/CDR0000041277 http://purl.bioontology.org/ontology/PDQ/CDR0000040410 http://purl.bioontology.org/ontology/PDQ/CDR0000039673 http://purl.bioontology.org/ontology/PDQ/CDR0000041237 http://purl.bioontology.org/ontology/PDQ/CDR0000039630 http://purl.bioontology.org/ontology/PDQ/CDR0000042208 http://purl.bioontology.org/ontology/PDQ/CDR0000038851 http://purl.bioontology.org/ontology/PDQ/CDR0000039043 http://purl.bioontology.org/ontology/PDQ/CDR0000041072 http://purl.bioontology.org/ontology/PDQ/CDR0000042371 http://purl.bioontology.org/ontology/PDQ/CDR0000041842 http://purl.bioontology.org/ontology/PDQ/CDR0000039119 http://purl.bioontology.org/ontology/PDQ/CDR0000042228 http://purl.bioontology.org/ontology/PDQ/CDR0000042330 http://purl.bioontology.org/ontology/PDQ/CDR0000040788 http://purl.bioontology.org/ontology/PDQ/CDR0000041066 http://purl.bioontology.org/ontology/PDQ/CDR0000043139 http://purl.bioontology.org/ontology/PDQ/CDR0000041083 http://purl.bioontology.org/ontology/PDQ/CDR0000040400 http://purl.bioontology.org/ontology/PDQ/CDR0000040126 http://purl.bioontology.org/ontology/PDQ/CDR0000041215 http://purl.bioontology.org/ontology/PDQ/CDR0000042377 http://purl.bioontology.org/ontology/PDQ/CDR0000041214 http://purl.bioontology.org/ontology/PDQ/CDR0000040495 http://purl.bioontology.org/ontology/PDQ/CDR0000039390 http://purl.bioontology.org/ontology/PDQ/CDR0000039572 http://purl.bioontology.org/ontology/PDQ/CDR0000042640 http://purl.bioontology.org/ontology/PDQ/CDR0000042177
cui	C1764853 C0729059 C1764854 C1765324 C1516302 C1516303 C1516301 C0007257 C1145713 C1527255
Date last modified	2018-05-17
definition	An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C349" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C349" NCI Thesaurus)
IND Code	969
Legacy PDQ ID	731
LT	TRD
NCI ID	C349
notation	CDR0000043027
NSC Code	409962
ORIG STY	Drug/agent
prefLabel	carmustine
tui	T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MESH/D002330	MESH	CUI
http://purl.bioontology.org/ontology/RCD/h12..	RCD	CUI
http://purl.bioontology.org/ontology/RCD/x02Vi	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/51326002	SCTSPA	CUI
http://purl.bioontology.org/ontology/VANDF/4020993	VANDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-78040	SNMI	CUI
http://purl.bioontology.org/ontology/MESH/D002330	MESH	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387281007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/786790001	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/786790001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/VANDF/4018136	VANDF	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148463	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146473	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006684	NDFRT	CUI
http://purl.bioontology.org/ontology/ATC/L01AD01	ATC	CUI
http://purl.bioontology.org/ontology/RXNORM/2105	RXNORM	CUI
http://purl.bioontology.org/ontology/SCTSPA/387281007	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/1371-8039	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D002330	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/51326002	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/002640	NDDF	CUI
http://purl.bioontology.org/ontology/SNMI/C-C1314	SNMI	CUI
http://purl.bioontology.org/ontology/MESH/D002330	MESH	CUI
http://purl.bioontology.org/ontology/RXNORM/343027	RXNORM	CUI
http://www.co-ode.org/ontologies/galen#Carmustine	GALEN	LOOM
http://purl.bioontology.org/ontology/RCD/h12..	RCD	LOOM
http://purl.obolibrary.org/obo/MESH_D002330	BERO	LOOM
http://www.drugbank.ca/drugs/DB00262	FTC	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78040	SNMI	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146473	ODAE	LOOM
http://purl.obolibrary.org/obo/NCIT_C349	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D002330	MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387281007	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.594.247	RH-MESH	LOOM
http://www.gamuts.net/entity#carmustine	GAMUTS	LOOM
http://purl.obolibrary.org/obo/DRON_00013638	ODNAE	LOOM
http://purl.bioontology.org/ontology/VANDF/4018136	VANDF	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_3423	NIFSTD	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017240	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/OMIT_0003664	OMIT	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146473	NDFRT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C349	NCIT	LOOM
http://purl.jp/bio/4/id/200906027295850967	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L01AD01	ATC	LOOM
https://go.drugbank.com/drugs/DB00262	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/2105	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002330	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2467	OCHV	LOOM
http://purl.bioontology.org/ontology/CSP/1371-8039	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.654.692.247	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/002640	NDDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0007257	OCHV	LOOM