loading...| Preferred Name | anakinra | |
| Synonyms |
interleukin-1 receptor antagonist IL-1ra Kineret |
|
| Definitions |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38717" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38717" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000043007 |
|
| altLabel |
interleukin-1 receptor antagonist IL-1ra Kineret |
|
| cui |
C0245109 C1170364 C1704264 |
|
| Date last modified |
2006-07-26 |
|
| definition |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38717" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C38717" NCI Thesaurus) |
|
| Legacy PDQ ID |
7263 |
|
| LT |
TRD |
|
| NCI ID |
C38717 |
|
| notation |
CDR0000043007 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
anakinra |
|
| tui |
T109 T116 T121 |