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Physician Data Query
Preferred Name | testolactone | |
Synonyms |
17alpha-oxo-D-homo-1,4-androstadiene-3,17-dione delta-1-testololactone 13-hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone TL therapeutic testolactone Teslac D-homo-17a-oxaandrosta-1,4-diene-3,17-dione 1-dehydrotestololactone 1,2,3,4,4a,4b,7,9,10,10a-decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone Fludestrin SQ-9538 |
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Definitions |
A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2301" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2301" NCI Thesaurus) |
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ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042916 |
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altLabel |
17alpha-oxo-D-homo-1,4-androstadiene-3,17-dione delta-1-testololactone 13-hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone TL therapeutic testolactone Teslac D-homo-17a-oxaandrosta-1,4-diene-3,17-dione 1-dehydrotestololactone 1,2,3,4,4a,4b,7,9,10,10a-decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone Fludestrin SQ-9538
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CAS Registry |
968-93-4
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cui |
C0039600 C0740162 C1527154 C1527155
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definition |
A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2301" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2301" NCI Thesaurus)
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IND Code |
920
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Legacy PDQ ID |
675
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LT |
TRD
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NCI ID |
C2301
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notation |
CDR0000042916
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NSC Code |
23759
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ORIG STY |
Drug/agent
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prefLabel |
testolactone
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tui |
T125 T109 T121
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