Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

testolactone
Synonyms

17alpha-oxo-D-homo-1,4-androstadiene-3,17-dione

delta-1-testololactone

13-hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone

TL

therapeutic testolactone

Teslac

D-homo-17a-oxaandrosta-1,4-diene-3,17-dione

1-dehydrotestololactone

1,2,3,4,4a,4b,7,9,10,10a-decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone

Fludestrin

SQ-9538

Definitions

A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2301" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2301" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042916

altLabel

17alpha-oxo-D-homo-1,4-androstadiene-3,17-dione

delta-1-testololactone

13-hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone

TL

therapeutic testolactone

Teslac

D-homo-17a-oxaandrosta-1,4-diene-3,17-dione

1-dehydrotestololactone

1,2,3,4,4a,4b,7,9,10,10a-decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone

Fludestrin

SQ-9538

CAS Registry

968-93-4

cui

C0039600

C0740162

C1527154

C1527155

definition

A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2301" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2301" NCI Thesaurus)

IND Code

920

Legacy PDQ ID

675

LT

TRD

NCI ID

C2301

notation

CDR0000042916

NSC Code

23759

ORIG STY

Drug/agent

prefLabel

testolactone

tui

T125

T109

T121

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/SCTSPA/63999004 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D013738 MESH CUI
http://purl.bioontology.org/ontology/NDDF/002665 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/404877009 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/63999004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D013738 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006220 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/404877009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-781F0 SNMI CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146097 NDFRT CUI
http://purl.bioontology.org/ontology/LNC/LP97957-2 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/10378 RXNORM CUI
http://purl.bioontology.org/ontology/VANDF/4017729 VANDF CUI
http://purl.bioontology.org/ontology/LNC/MTHU035163 LOINC CUI
http://purl.bioontology.org/ontology/MESH/D013738 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_9460 DRON LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018523 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.496.699 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002665 NDDF LOOM
http://purl.obolibrary.org/obo/dinto_DB00894 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013738 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/63999004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0014593 OMIT LOOM
http://purl.obolibrary.org/obo/MESH_D013738 BERO LOOM
http://purl.bioontology.org/ontology/SNMI/C-781F0 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146097 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP97957-2 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9460 NIFSTD LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2301 NCIT LOOM
http://purl.jp/bio/4/id/200906045538241229 IOBC LOOM
https://go.drugbank.com/drugs/DB00894 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/10378 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.054.079.129.782 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4017729 VANDF LOOM
http://stirdf.jst.go.jp/id/200907038514446145 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C2301 BERO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035163 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D013738 MESH LOOM
http://www.drugbank.ca/drugs/DB00894 FTC LOOM