Preferred Name | paroxetine hydrochloride | |
Synonyms |
Paxil |
|
Definitions |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1837" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1837" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042793 |
|
altLabel |
Paxil |
|
CAS Registry |
78246-49-8 |
|
cui |
C0376414 C0771019 |
|
Date last modified |
2006-05-11 |
|
definition |
The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1837" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1837" NCI Thesaurus) |
|
Legacy PDQ ID |
6592 |
|
LT |
TRD |
|
NCI ID |
C1837 |
|
notation |
CDR0000042793 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
paroxetine hydrochloride |
|
tui |
T109 T121 |