loading...| Preferred Name |
troglitazone |
|
| Synonyms |
5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione |
|
| Definitions |
An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1522" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1522" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042706 |
|
| altLabel |
5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione Prelay CI-991 CS-045 Romozin Rezulin 5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione |
|
| CAS Registry |
97322-87-7 |
|
| cui |
C1527015 C1097080 C0595409 C0056565 C0245514 C0701265 |
|
| definition |
An orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1522" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1522" NCI Thesaurus) |
|
| Legacy PDQ ID |
6498 |
|
| LT |
TRD |
|
| NCI ID |
C1522 |
|
| notation |
CDR0000042706 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
troglitazone |
|
| tui |
T109 T121 |