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Physician Data Query
| Preferred Name | lamivudine | |
| Synonyms |
3TC LAM Epivir |
|
| Definitions |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1471" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1471" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042593 |
|
| altLabel |
3TC LAM Epivir
|
|
| CAS Registry |
134678-17-4
|
|
| Component of | ||
| cui |
C0209738 C0678151
|
|
| Date last modified |
2016-02-05
|
|
| definition |
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1471" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1471" NCI Thesaurus)
|
|
| Legacy PDQ ID |
6297
|
|
| LT |
TRD
|
|
| NCI ID |
C1471
|
|
| notation |
CDR0000042593
|
|
| ORIG STY |
Drug/agent
|
|
| prefLabel |
lamivudine
|
|
| tui |
T114 T121
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