loading...| Preferred Name | oxaliplatin | |
| Synonyms |
oxalatoplatin Eloxatine Dacotin L-OHP Ai Heng oxalatoplatinum Dacplat RP-54780 Aiheng Eloxatin [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum oxalato (1R,2R-cyclohexanediamine)platinum(II) JM-83 [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum trans-l diaminocyclohexane oxalatoplatinum oxalato (trans-l-1,2-diaminocyclohexane)platinum(II) diaminocyclohexane oxalatoplatinum 1-OHP SR-96669 trans-l DACH oxalatoplatinum oxaliplatine |
|
| Definitions |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1181" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1181" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042374 |
|
| altLabel |
oxalatoplatin Eloxatine Dacotin L-OHP Ai Heng oxalatoplatinum Dacplat RP-54780 Aiheng Eloxatin [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum oxalato (1R,2R-cyclohexanediamine)platinum(II) JM-83 [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum trans-l diaminocyclohexane oxalatoplatinum oxalato (trans-l-1,2-diaminocyclohexane)platinum(II) diaminocyclohexane oxalatoplatinum 1-OHP SR-96669 trans-l DACH oxalatoplatinum oxaliplatine |
|
| CAS Registry |
63121-00-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038114 http://purl.bioontology.org/ontology/PDQ/CDR0000405348 http://purl.bioontology.org/ontology/PDQ/CDR0000277247 http://purl.bioontology.org/ontology/PDQ/CDR0000434417 http://purl.bioontology.org/ontology/PDQ/CDR0000409775 http://purl.bioontology.org/ontology/PDQ/CDR0000341569 http://purl.bioontology.org/ontology/PDQ/CDR0000043545 http://purl.bioontology.org/ontology/PDQ/CDR0000417736 http://purl.bioontology.org/ontology/PDQ/CDR0000410879 http://purl.bioontology.org/ontology/PDQ/CDR0000405927 http://purl.bioontology.org/ontology/PDQ/CDR0000037988 http://purl.bioontology.org/ontology/PDQ/CDR0000037904 http://purl.bioontology.org/ontology/PDQ/CDR0000355415 http://purl.bioontology.org/ontology/PDQ/CDR0000445585 http://purl.bioontology.org/ontology/PDQ/CDR0000369989 http://purl.bioontology.org/ontology/PDQ/CDR0000440879 http://purl.bioontology.org/ontology/PDQ/CDR0000043141 http://purl.bioontology.org/ontology/PDQ/CDR0000037791 http://purl.bioontology.org/ontology/PDQ/CDR0000319029 http://purl.bioontology.org/ontology/PDQ/CDR0000256418 http://purl.bioontology.org/ontology/PDQ/CDR0000377335 http://purl.bioontology.org/ontology/PDQ/CDR0000038009 http://purl.bioontology.org/ontology/PDQ/CDR0000037846 http://purl.bioontology.org/ontology/PDQ/CDR0000285685 http://purl.bioontology.org/ontology/PDQ/CDR0000038445 http://purl.bioontology.org/ontology/PDQ/CDR0000043650 http://purl.bioontology.org/ontology/PDQ/CDR0000037836 http://purl.bioontology.org/ontology/PDQ/CDR0000360858 http://purl.bioontology.org/ontology/PDQ/CDR0000038454 http://purl.bioontology.org/ontology/PDQ/CDR0000373894 http://purl.bioontology.org/ontology/PDQ/CDR0000353334 http://purl.bioontology.org/ontology/PDQ/CDR0000043367 http://purl.bioontology.org/ontology/PDQ/CDR0000362073 http://purl.bioontology.org/ontology/PDQ/CDR0000038134 http://purl.bioontology.org/ontology/PDQ/CDR0000329910 http://purl.bioontology.org/ontology/PDQ/CDR0000038463 http://purl.bioontology.org/ontology/PDQ/CDR0000037898 http://purl.bioontology.org/ontology/PDQ/CDR0000331850 http://purl.bioontology.org/ontology/PDQ/CDR0000410680 |
|
| cui |
C1518757 C1135117 C1518756 C1522139 C0954916 C0069717 C1522140 C1522141 C4086991 |
|
| Date last modified |
2016-03-24 |
|
| definition |
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1181" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1181" NCI Thesaurus) |
|
| IND Code |
57004 |
|
| Legacy PDQ ID |
5628 |
|
| LT |
TRD |
|
| NCI ID |
C1181 |
|
| notation |
CDR0000042374 |
|
| NSC Code |
266046 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
oxaliplatin |
|
| tui |
T109 T121 |