Physician Data Query

Last uploaded: August 28, 2024
Jump to:
Preferred Name

bexarotene
Synonyms

4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

3-methyl TTNEB

Targretin

LGD1069
Definitions

A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1635" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1635" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042117
altLabel

4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

3-methyl TTNEB

Targretin

LGD1069
CAS Registry

153559-49-0
Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000042441

http://purl.bioontology.org/ontology/PDQ/CDR0000038538

http://purl.bioontology.org/ontology/PDQ/CDR0000038633
cui

C0813158

C0300770

C0765273
Date last modified

2006-07-27
definition

A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1635" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1635" NCI Thesaurus)
Legacy PDQ ID

5353
LT

TRD
NCI ID

C1635
notation

CDR0000042117
ORIG STY

Drug/agent
prefLabel

bexarotene
tui

T109

T121
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/258324 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077610 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/116346006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000077610 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077610 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4021197 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/387023000 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006359 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/116346006 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148643 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387023000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/233272 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077610 MSHFRE CUI
http://purl.bioontology.org/ontology/ATC/L01XF03 ATC CUI
http://purl.bioontology.org/ontology/NDDF/008004 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D000077610 MESH CUI
http://purl.obolibrary.org/obo/CHEBI_50859 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48632 OCHV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148643 ODAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0765273 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4021197 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_50859 NIFSTD LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026196 PMAPP-PMO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1635 NCIT LOOM
http://purl.obolibrary.org/obo/DRON_00013784 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C1635 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148643 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387023000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/233272 RXNORM LOOM
http://doe-generated-ontology.com/OntoAD#C0765273 ONTOAD LOOM
http://www.drugbank.ca/drugs/DB00307 FTC LOOM
http://purl.bioontology.org/ontology/ATC/L01XF03 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C095105 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00307 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/008004 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/D000077610 MESH LOOM