Physician Data Query

Last uploaded: August 28, 2024
Preferred Name

letrozole
Synonyms

4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile

LTZ

Femara

CGS 20267

Definitions

A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1527" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1527" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042086

altLabel

4,4'-(1H-1,2,4triazol-1-ylmethylene)dibenzonitrile

LTZ

Femara

CGS 20267

CAS Registry

112809-51-5

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000410777

http://purl.bioontology.org/ontology/PDQ/CDR0000415928

http://purl.bioontology.org/ontology/PDQ/CDR0000042379

http://purl.bioontology.org/ontology/PDQ/CDR0000305872

http://purl.bioontology.org/ontology/PDQ/CDR0000301892

http://purl.bioontology.org/ontology/PDQ/CDR0000429572

cui

C0701347

C0701348

C0246421

Date last modified

2009-12-15

definition

A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1527" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1527" NCI Thesaurus)

Legacy PDQ ID

5321

LT

TRD

NCI ID

C1527

notation

CDR0000042086

NSC Code

719345

ORIG STY

Drug/agent

prefLabel

letrozole

tui

T109

T121

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Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D000077289 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077289 MESH CUI
http://purl.bioontology.org/ontology/LNC/LP437032-8 LOINC CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077289 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/LA14343-0 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/203769 RXNORM CUI
http://purl.bioontology.org/ontology/RCD/x03vB RCD CUI
http://purl.bioontology.org/ontology/MESH/D000077289 MESH CUI
http://purl.bioontology.org/ontology/LNC/MTHU069929 LOINC CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077289 MSHFRE CUI
http://purl.bioontology.org/ontology/NDDF/006298 NDDF CUI
http://purl.bioontology.org/ontology/RCD/heE.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148513 NDFRT CUI
http://purl.bioontology.org/ontology/ATC/L02BG04 ATC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006777 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/108777007 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108777007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/386911004 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/72965 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386911004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4021049 VANDF CUI
http://purl.obolibrary.org/obo/CHEBI_6413 DRON LOOM
http://purl.bioontology.org/ontology/LNC/LP437032-8 LOINC LOOM
http://purl.bioontology.org/ontology/MESH/D000077289 MESH LOOM
http://purl.obolibrary.org/obo/XCO_0001327 XCO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026175 PMAPP-PMO LOOM
http://www.drugbank.ca/drugs/DB01006 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU069929 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C1527 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/006298 NDDF LOOM
https://go.drugbank.com/drugs/DB01006 MDM LOOM
http://purl.jp/bio/4/id/200906050381941110 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067431 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Letrozole GALEN LOOM
http://purl.bioontology.org/ontology/RCD/heE.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148513 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/L02BG04 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25142 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0246421 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1527 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6413 NIFSTD LOOM
http://stirdf.jst.go.jp/id/200907081310334197 IOBC LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass731d61fb_cd1b_4ae6_b7cc_326a9444e994 WWECA LOOM
http://purl.bioontology.org/ontology/RXNORM/72965 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/72965 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386911004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021049 VANDF LOOM