Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

loperamide hydrochloride

Synonyms

Imodium A-D

Definitions

The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1584" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1584" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041911

altLabel

Imodium A-D

CAS Registry

34552-83-5

cui

C0282221

C0721047

Date last modified

2007-01-24

definition

The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1584" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1584" NCI Thesaurus)

Legacy PDQ ID

5129

LT

TRD

NCI ID

C1584

notation

CDR0000041911

ORIG STY

Drug/agent

prefLabel

loperamide hydrochloride

tui

T109

T121

Delete Subject Author Type Created
No notes to display