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Last uploaded: August 28, 2024

Preferred Name	procarbazine hydrochloride
Synonyms	Matulane p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) Ro 4-6467/1 p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride PCZ ibenzmethyzin hydrochloride Natulanar N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride MIH hydrochloride N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) PCB PCB hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride Natulan NCI-C01810
Definitions	The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C773" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C773" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000041607
altLabel	Matulane p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI) Ro 4-6467/1 p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride PCZ ibenzmethyzin hydrochloride Natulanar N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride MIH hydrochloride N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) PCB PCB hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride Natulan NCI-C01810
CAS Registry	366-70-1
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000041092 http://purl.bioontology.org/ontology/PDQ/CDR0000039428 http://purl.bioontology.org/ontology/PDQ/CDR0000040239 http://purl.bioontology.org/ontology/PDQ/CDR0000041320 http://purl.bioontology.org/ontology/PDQ/CDR0000039403 http://purl.bioontology.org/ontology/PDQ/CDR0000039382 http://purl.bioontology.org/ontology/PDQ/CDR0000040344 http://purl.bioontology.org/ontology/PDQ/CDR0000040982 http://purl.bioontology.org/ontology/PDQ/CDR0000039356 http://purl.bioontology.org/ontology/PDQ/CDR0000040282 http://purl.bioontology.org/ontology/PDQ/CDR0000039599 http://purl.bioontology.org/ontology/PDQ/CDR0000039682 http://purl.bioontology.org/ontology/PDQ/CDR0000344418 http://purl.bioontology.org/ontology/PDQ/CDR0000042619 http://purl.bioontology.org/ontology/PDQ/CDR0000039709 http://purl.bioontology.org/ontology/PDQ/CDR0000039383 http://purl.bioontology.org/ontology/PDQ/CDR0000041652 http://purl.bioontology.org/ontology/PDQ/CDR0000039573 http://purl.bioontology.org/ontology/PDQ/CDR0000043215 http://purl.bioontology.org/ontology/PDQ/CDR0000039380 http://purl.bioontology.org/ontology/PDQ/CDR0000357354 http://purl.bioontology.org/ontology/PDQ/CDR0000042611 http://purl.bioontology.org/ontology/PDQ/CDR0000041843 http://purl.bioontology.org/ontology/PDQ/CDR0000043553 http://purl.bioontology.org/ontology/PDQ/CDR0000039399 http://purl.bioontology.org/ontology/PDQ/CDR0000304318 http://purl.bioontology.org/ontology/PDQ/CDR0000039977 http://purl.bioontology.org/ontology/PDQ/CDR0000039684 http://purl.bioontology.org/ontology/PDQ/CDR0000040936 http://purl.bioontology.org/ontology/PDQ/CDR0000040419 http://purl.bioontology.org/ontology/PDQ/CDR0000042644 http://purl.bioontology.org/ontology/PDQ/CDR0000042129 http://purl.bioontology.org/ontology/PDQ/CDR0000040147 http://purl.bioontology.org/ontology/PDQ/CDR0000041030 http://purl.bioontology.org/ontology/PDQ/CDR0000039395 http://purl.bioontology.org/ontology/PDQ/CDR0000041175 http://purl.bioontology.org/ontology/PDQ/CDR0000040866 http://purl.bioontology.org/ontology/PDQ/CDR0000039377 http://purl.bioontology.org/ontology/PDQ/CDR0000040420 http://purl.bioontology.org/ontology/PDQ/CDR0000042038 http://purl.bioontology.org/ontology/PDQ/CDR0000039695 http://purl.bioontology.org/ontology/PDQ/CDR0000042857 http://purl.bioontology.org/ontology/PDQ/CDR0000043123 http://purl.bioontology.org/ontology/PDQ/CDR0000043723 http://purl.bioontology.org/ontology/PDQ/CDR0000042001 http://purl.bioontology.org/ontology/PDQ/CDR0000043520 http://purl.bioontology.org/ontology/PDQ/CDR0000043063 http://purl.bioontology.org/ontology/PDQ/CDR0000355820 http://purl.bioontology.org/ontology/PDQ/CDR0000039519 http://purl.bioontology.org/ontology/PDQ/CDR0000040494 http://purl.bioontology.org/ontology/PDQ/CDR0000040333 http://purl.bioontology.org/ontology/PDQ/CDR0000042161 http://purl.bioontology.org/ontology/PDQ/CDR0000040954 http://purl.bioontology.org/ontology/PDQ/CDR0000041602 http://purl.bioontology.org/ontology/PDQ/CDR0000040066 http://purl.bioontology.org/ontology/PDQ/CDR0000039778 http://purl.bioontology.org/ontology/PDQ/CDR0000040964 http://purl.bioontology.org/ontology/PDQ/CDR0000039343 http://purl.bioontology.org/ontology/PDQ/CDR0000039401 http://purl.bioontology.org/ontology/PDQ/CDR0000039400 http://purl.bioontology.org/ontology/PDQ/CDR0000039338 http://purl.bioontology.org/ontology/PDQ/CDR0000040985
cui	C0205909 C1522607 C0701390 C1514466 C0033223 C0701389 C1522606
Date last modified	2017-12-11
definition	The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C773" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C773" NCI Thesaurus)
IND Code	7180
Legacy PDQ ID	477
LT	TRD
NCI ID	C773
notation	CDR0000041607
NSC Code	77213
ORIG STY	Drug/agent
prefLabel	procarbazine hydrochloride
tui	T109 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SNMI/C-781C1	SNMI	CUI
http://purl.bioontology.org/ontology/MESH/D011344	MESH	CUI
http://purl.bioontology.org/ontology/SNMI/C-781C0	SNMI	CUI
http://purl.bioontology.org/ontology/MESH/D011344	MESH	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179360	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146150	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011344	MSHFRE	CUI
http://purl.bioontology.org/ontology/MESH/D011344	MESH	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/10174003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/002672	NDDF	CUI
http://purl.bioontology.org/ontology/VANDF/4017789	VANDF	CUI
http://purl.bioontology.org/ontology/RXNORM/66925	RXNORM	CUI
http://purl.bioontology.org/ontology/SCTSPA/10174003	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/203801	RXNORM	CUI
http://purl.bioontology.org/ontology/SNMI/C-781C1	SNMI	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011344	MSHFRE	CUI
http://purl.bioontology.org/ontology/MESH/D011344	MESH	CUI
http://purl.bioontology.org/ontology/SCTSPA/387474003	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/10174003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/ATC/L01XB01	ATC	CUI
http://purl.bioontology.org/ontology/NDDF/004827	NDDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/10174003	SCTSPA	CUI
http://purl.bioontology.org/ontology/RXNORM/8702	RXNORM	CUI
http://purl.bioontology.org/ontology/CSP/0316-4491	CRISP	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/81583003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387474003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RCD/h57..	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/81583003	SCTSPA	CUI
http://purl.bioontology.org/ontology/VANDF/4019906	VANDF	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005818	NDFRT	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147991	NDFRT	CUI
http://purl.bioontology.org/ontology/RCD/x02kV	RCD	CUI
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	LOOM
http://purl.bioontology.org/ontology/SNMI/C-781C1	SNMI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146150	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/10174003	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/NCIT_C773	BERO	LOOM
http://www.co-ode.org/ontologies/galen#ProcarbazineHydrochloride	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0205909	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C773	NCIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_71428	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_71428	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4017789	VANDF	LOOM
http://purl.bioontology.org/ontology/RXNORM/66925	RXNORM	LOOM