procarbazine hydrochloride

Matulane

The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C773" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C773" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000041607

Matulane

p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)

Ro 4-6467/1

p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride

PCZ

ibenzmethyzin hydrochloride

Natulanar

N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride

MIH hydrochloride

N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride

benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)

PCB

PCB hydrochloride

N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride

Natulan

NCI-C01810

366-70-1

http://purl.bioontology.org/ontology/PDQ/CDR0000041092

http://purl.bioontology.org/ontology/PDQ/CDR0000039428

http://purl.bioontology.org/ontology/PDQ/CDR0000040239

http://purl.bioontology.org/ontology/PDQ/CDR0000041320

http://purl.bioontology.org/ontology/PDQ/CDR0000039403

http://purl.bioontology.org/ontology/PDQ/CDR0000039382

http://purl.bioontology.org/ontology/PDQ/CDR0000040344

http://purl.bioontology.org/ontology/PDQ/CDR0000040982

http://purl.bioontology.org/ontology/PDQ/CDR0000039356

http://purl.bioontology.org/ontology/PDQ/CDR0000040282

http://purl.bioontology.org/ontology/PDQ/CDR0000039599

http://purl.bioontology.org/ontology/PDQ/CDR0000039682

http://purl.bioontology.org/ontology/PDQ/CDR0000344418

http://purl.bioontology.org/ontology/PDQ/CDR0000042619

http://purl.bioontology.org/ontology/PDQ/CDR0000039709

http://purl.bioontology.org/ontology/PDQ/CDR0000039383

http://purl.bioontology.org/ontology/PDQ/CDR0000041652

http://purl.bioontology.org/ontology/PDQ/CDR0000039573

http://purl.bioontology.org/ontology/PDQ/CDR0000043215

http://purl.bioontology.org/ontology/PDQ/CDR0000039380

http://purl.bioontology.org/ontology/PDQ/CDR0000357354

http://purl.bioontology.org/ontology/PDQ/CDR0000042611

http://purl.bioontology.org/ontology/PDQ/CDR0000041843

http://purl.bioontology.org/ontology/PDQ/CDR0000043553

http://purl.bioontology.org/ontology/PDQ/CDR0000039399

http://purl.bioontology.org/ontology/PDQ/CDR0000304318

http://purl.bioontology.org/ontology/PDQ/CDR0000039977

http://purl.bioontology.org/ontology/PDQ/CDR0000039684

http://purl.bioontology.org/ontology/PDQ/CDR0000040936

http://purl.bioontology.org/ontology/PDQ/CDR0000040419

http://purl.bioontology.org/ontology/PDQ/CDR0000042644

http://purl.bioontology.org/ontology/PDQ/CDR0000042129

http://purl.bioontology.org/ontology/PDQ/CDR0000040147

http://purl.bioontology.org/ontology/PDQ/CDR0000041030

http://purl.bioontology.org/ontology/PDQ/CDR0000039395

http://purl.bioontology.org/ontology/PDQ/CDR0000041175

http://purl.bioontology.org/ontology/PDQ/CDR0000040866

http://purl.bioontology.org/ontology/PDQ/CDR0000039377

http://purl.bioontology.org/ontology/PDQ/CDR0000040420

http://purl.bioontology.org/ontology/PDQ/CDR0000042038

http://purl.bioontology.org/ontology/PDQ/CDR0000039695

http://purl.bioontology.org/ontology/PDQ/CDR0000042857

http://purl.bioontology.org/ontology/PDQ/CDR0000043123

http://purl.bioontology.org/ontology/PDQ/CDR0000043723

http://purl.bioontology.org/ontology/PDQ/CDR0000042001

http://purl.bioontology.org/ontology/PDQ/CDR0000043520

http://purl.bioontology.org/ontology/PDQ/CDR0000043063

http://purl.bioontology.org/ontology/PDQ/CDR0000355820

http://purl.bioontology.org/ontology/PDQ/CDR0000039519

http://purl.bioontology.org/ontology/PDQ/CDR0000040494

http://purl.bioontology.org/ontology/PDQ/CDR0000040333

http://purl.bioontology.org/ontology/PDQ/CDR0000042161

http://purl.bioontology.org/ontology/PDQ/CDR0000040954

http://purl.bioontology.org/ontology/PDQ/CDR0000041602

http://purl.bioontology.org/ontology/PDQ/CDR0000040066

http://purl.bioontology.org/ontology/PDQ/CDR0000039778

http://purl.bioontology.org/ontology/PDQ/CDR0000040964

http://purl.bioontology.org/ontology/PDQ/CDR0000039343

http://purl.bioontology.org/ontology/PDQ/CDR0000039401

http://purl.bioontology.org/ontology/PDQ/CDR0000039400

http://purl.bioontology.org/ontology/PDQ/CDR0000039338

http://purl.bioontology.org/ontology/PDQ/CDR0000040985

C0205909

C1522607

C0701390

C1514466

C0033223

C0701389

C1522606

2017-12-11

The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C773" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C773" NCI Thesaurus)

7180

477

TRD

C773

CDR0000041607

77213

Drug/agent

procarbazine hydrochloride

T109

T121