loading...| Preferred Name | albuterol sulfate | |
| Synonyms |
Proventil Ventolin salbutamol sulfate |
|
| Definitions |
The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47957" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47957" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041339 |
|
| altLabel |
Proventil Ventolin salbutamol sulfate |
|
| CAS Registry |
51022-70-9 |
|
| cui |
C0699770 C0543495 C0033744 |
|
| Date last modified |
2008-02-21 |
|
| definition |
The sulfate salt of the short-acting sympathomimetic agent albuterol, a 1:1 racemic mixture of (R)-albuterol and (S)-albuterol with bronchodilator activity. Albuterol stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. To a lesser extent albuterol stimulates beta1-adrenergic receptors, thereby increasing the force and rate of myocardial contraction. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47957" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47957" NCI Thesaurus) |
|
| Legacy PDQ ID |
4411 |
|
| LT |
TRD |
|
| NCI ID |
C47957 |
|
| notation |
CDR0000041339 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
albuterol sulfate |
|
| tui |
T109 T121 |