Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

clonidine hydrochloride
Synonyms

Catapres
Definitions

The hydrochloride salt form of clonidine, an imidazoline derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity. Clonidine hydrochloride binds to and stimulates central alpha-2 adrenergic receptors, thereby decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow, leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47979" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47979" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041228
altLabel

Catapres
CAS Registry

4205-91-8
cui

C0699881

C0546860
Date last modified

2017-11-28
definition

The hydrochloride salt form of clonidine, an imidazoline derivate and centrally-acting alpha-adrenergic agonist as well as antagonist with antihypertensive activity. Clonidine hydrochloride binds to and stimulates central alpha-2 adrenergic receptors, thereby decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow, leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47979" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47979" NCI Thesaurus)
Legacy PDQ ID

4301
LT

TRD
NCI ID

C47979
notation

CDR0000041228
ORIG STY

Drug/agent
prefLabel

clonidine hydrochloride
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D003000 MESH CUI
http://purl.bioontology.org/ontology/SNMI/C-81131 SNMI CUI
http://purl.bioontology.org/ontology/RCD/x02Wv RCD CUI
http://purl.bioontology.org/ontology/RXNORM/202941 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D003000 MSHFRE CUI
http://purl.bioontology.org/ontology/SCTSPA/387121001 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179536 NDFRT CUI
http://purl.bioontology.org/ontology/NDDF/000644 NDDF CUI
http://purl.bioontology.org/ontology/MESH/D003000 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4017849 VANDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146206 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387121001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/142432 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-81131 SNMI LOOM
http://purl.obolibrary.org/obo/NCIT_C47979 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3758 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3758 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38849 OCHV LOOM
http://stirdf.jst.go.jp/id/200907077777925876 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4017849 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146206 NDFRT LOOM
http://purl.jp/bio/4/id/200906013401382276 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387121001 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47979 NCIT LOOM
http://www.co-ode.org/ontologies/galen#ClonidineHydrochloride GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146206 OCVDAE LOOM
http://purl.bioontology.org/ontology/RXNORM/142432 RXNORM LOOM